SCHEMBL20041042

SCHEMBL20041042

O=CNc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDR P35968 20/20 0.60
BRAF P15056 16/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20881488 0.85 KDR (0.66) KDRBRAF
SCHEMBL15542391 0.83 KDR (0.59) KDRBRAF
SCHEMBL16907377 0.80 KDR (0.62) KDRBRAF
SCHEMBL1892874 0.78 KDR (0.54) KDRBRAF
SCHEMBL24932207 0.78 KDR (0.63) KDRBRAF
SCHEMBL1897809 0.77 KDR (0.71) KDRBRAF
SCHEMBL16036682 0.77 KDR (0.56) KDRBRAF
SCHEMBL16904536 0.76 KDR (0.58) KDRBRAF
SCHEMBL20881298 0.76 KDR (0.61) KDRBRAF
SCHEMBL15542274 0.76 KDR (0.61) KDRBRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2864289-B1 CYCLOPROPANECARBOXAMIDO-SUBSTITUTED AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS CB THERAPEUTICS INC (KY) 2018-04-11 EP disclosed