Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.63 |
| ▸ | BRAF | P15056 | 11/20 | 0.63 |
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16904537 | 0.92 | KDR (0.58) | KDRBRAFABL1 | |
| SCHEMBL20040800 | 0.83 | KDR (0.66) | KDRBRAF | |
| SCHEMBL15542114 | 0.83 | KDR (0.60) | KDRBRAF | |
| SCHEMBL15542391 | 0.82 | KDR (0.59) | KDRBRAFABL1 | |
| SCHEMBL24931469 | 0.82 | ABL1 (0.61) | KDRBRAFABL1 | |
| SCHEMBL15559536 | 0.81 | KDR (0.69) | KDRBRAF | |
| SCHEMBL31521720 | 0.80 | ACVRL1 (0.61) | — | |
| SCHEMBL21963566 | 0.80 | ACVRL1 (0.61) | — | |
| SCHEMBL20881488 | 0.80 | KDR (0.66) | KDRBRAF | |
| SCHEMBL24931476 | 0.79 | GCK (0.49) | KDRBRAFABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901280-B | MrgprX2 antagonists and uses thereof | 德米拉公司 | 2025-05-27 | — | — | CN | disclosed |
| US-20230027929-A1 | MrgprX2 Antagonists and Uses Thereof | DERMIRA, INC. | 2023-01-26 | — | — | US | disclosed |
| CN-114901280-A | MrgprX2 antagonists and uses thereof | 德米拉公司 | 2022-08-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230027929-A1 | MrgprX2 Antagonists and Uses Thereof | MRGPRX2, MRGPRX1, MRGPRX4 | KDR 1665/4885BRAF 3783/4885ABL1 4562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.