Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.61 |
| ▸ | NPC1 | O15118 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | LDHA | P00338 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8470440 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL84327 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL30542465 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL378504 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL2615304 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL31036744 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL1218824 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL906835 | 0.76 | HTT (0.61) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL2615303 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL1878015 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882439-B1 | APOPTOSIS-INDUCING AGENTS | ABBVIE INC (US) | 2018-04-11 | — | — | EP | disclosed |