Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | RGS12 | O14924 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1892817 | 0.87 | GAA (1.00) | GAAMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL30636606 | 0.87 | GAA (1.00) | GAAMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL15887331 | 0.85 | GAA (0.56) | GAAMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL12053302 | 0.79 | GAA (0.50) | GAAMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL6598569 | 0.79 | MEN1 (0.47) | GAAMEN1ALDH1A1KMT2ANPC1 | |
| Phenylacetic Acid SCHEMBL10765351 | 0.79 | GAA (0.65) | GAAMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL20564248 | 0.78 | ALDH1A1 (0.49) | GAAMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL28063797 | 0.76 | MEN1 (0.45) | GAAMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL355077 | 0.75 | DYRK1A (0.49) | GAAMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL3815115 | 0.75 | DYRK1A (0.45) | GAAMEN1ALDH1A1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230060990-A1 | TREATMENT OF NEURODEGENERATIVE DISEASES THROUGH INHIBITON OF HSP90 | SLOAN KETTERING INST CANCER RES (US) | 2023-03-02 | — | — | US | disclosed |
| EP-3305297-A1 | TREATMENT OF NEURODEGENERATIVE DISEASES THROUGH INHIBITION OF HSP90 | Sloan-Kettering Institute for Cancer Research (US) | 2018-04-11 | — | — | EP | disclosed |
| CN-1345314-A | Amine derivatives as protease inhibitors | AXYS PHARM INC (US) | 2002-04-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230060990-A1 | TREATMENT OF NEURODEGENERATIVE DISEASES THROUGH INHIBITON OF HSP90 | HSP90B1, HSP90AB1, HSP90AB2P | GAA 219/4885MEN1 4707/4885ALDH1A1 1998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.