Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 6/20 | 0.61 |
| ▸ | CDK9 | P50750 | 6/20 | 0.61 |
| ▸ | CDK2 | P24941 | 6/20 | 0.61 |
| ▸ | CCNK | O75909 | 4/20 | 0.61 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.61 |
| ▸ | CDK7 | P50613 | 6/20 | 0.53 |
| ▸ | CCNH | P51946 | 6/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.53 |
| ▸ | EGFR | P00533 | 7/20 | 0.47 |
| ▸ | JUN | P05412 | 4/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26967533 | 1.00 | CCNT1 (0.61) | CCNT1CDK9CDK2CCNKCDK12 | |
| SCHEMBL16665199 | 0.89 | CDK7 (0.58) | CCNT1CDK9CDK2CCNKCDK12 | |
| SCHEMBL23152039 | 0.89 | CDK2 (0.52) | CCNT1CDK9CDK2CCNKCDK12 | |
| SCHEMBL20190356 | 0.89 | CDK2 (0.52) | CCNT1CDK9CDK2CCNKCDK12 | |
| SCHEMBL25593200 | 0.88 | CDK7 (0.65) | CCNT1CDK9CDK2CCNKCDK12 | |
| SCHEMBL17141074 | 0.87 | CCNT1 (0.49) | CCNT1CDK9CDK2CCNKCDK12 | |
| SCHEMBL19605654 | 0.86 | CDK7 (0.53) | CCNT1CDK9CDK2CCNKCDK12 | |
| SCHEMBL16665131 | 0.86 | CDK7 (0.55) | CCNT1CDK9CDK2CCNKCDK12 | |
| SCHEMBL16655047 | 0.86 | HTR6 (0.53) | CCNT1CDK9CDK2CCNKCDK12 | |
| SCHEMBL29613414 | 0.86 | HTR6 (0.53) | CCNT1CDK9CDK2CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4295852-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| EP-3057955-B1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | SYROS PHARMACEUTICALS INC (US) | 2018-04-11 | — | — | EP | disclosed |