Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 13/20 | 0.48 |
| ▸ | CDK2 | P24941 | 13/20 | 0.48 |
| ▸ | CCNH | P51946 | 11/20 | 0.48 |
| ▸ | CDK9 | P50750 | 10/20 | 0.48 |
| ▸ | CCNK | O75909 | 10/20 | 0.48 |
| ▸ | CDK12 | Q9NYV4 | 10/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.48 |
| ▸ | MNAT1 | P51948 | 9/20 | 0.48 |
| ▸ | CDK13 | Q14004 | 7/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.48 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.47 |
| ▸ | JUN | P05412 | 5/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16655056 | 0.84 | CDK7 (0.48) | CDK7CDK2CCNHCDK9CCNK | |
| SCHEMBL18045081 | 0.84 | CDK7 (0.48) | CDK7CDK2CCNHCDK9CCNK | |
| SCHEMBL17150554 | 0.81 | CDK7 (0.54) | CDK7CDK2CCNHCDK9CCNK | |
| SCHEMBL16654810 | 0.80 | CDK2 (0.48) | CDK7CDK2CCNHCDK9CCNK | |
| SCHEMBL16655415 | 0.80 | CDK2 (0.48) | CDK7CDK2CCNHCDK9CCNK | |
| SCHEMBL16654808 | 0.80 | CDK2 (0.48) | CDK7CDK2CCNHCDK9CCNK | |
| SCHEMBL20041398 | 0.80 | CDK2 (0.73) | CDK7CDK2CCNHCDK9CCNK | |
| SCHEMBL21561673 | 0.80 | CDK2 (0.73) | CDK7CDK2CCNHCDK9CCNK | |
| SCHEMBL16664898 | 0.76 | CDK2 (0.47) | CDK7CDK2CCNHCDK9CCNK | |
| SCHEMBL18045073 | 0.76 | CDK2 (0.47) | CDK7CDK2CCNHCDK9CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057955-B1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | SYROS PHARMACEUTICALS INC (US) | 2018-04-11 | — | — | EP | disclosed |