Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.69 |
| ▸ | JUN | P05412 | 10/20 | 0.69 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 10/20 | 0.69 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.69 |
| ▸ | CCNK | O75909 | 10/20 | 0.67 |
| ▸ | CDK12 | Q9NYV4 | 10/20 | 0.67 |
| ▸ | CDK9 | P50750 | 9/20 | 0.67 |
| ▸ | CDK7 | P50613 | 9/20 | 0.67 |
| ▸ | CCNH | P51946 | 9/20 | 0.67 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.67 |
| ▸ | CDK13 | Q14004 | 7/20 | 0.67 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.67 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21234360 | 1.00 | CDK2 (0.69) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL20041398 | 0.89 | CDK2 (0.73) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL21561673 | 0.89 | CDK2 (0.73) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL18313056 | 0.89 | CDK2 (0.75) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL16654839 | 0.85 | CDK2 (0.73) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL16654836 | 0.85 | CDK2 (0.73) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL16655011 | 0.85 | CDK2 (0.73) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL21561657 | 0.84 | CCNK (0.83) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL21561669 | 0.83 | CDK2 (0.74) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL21561671 | 0.83 | CDK7 (0.76) | CDK2JUNMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057955-B1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | SYROS PHARMACEUTICALS INC (US) | 2018-04-11 | — | — | EP | disclosed |