Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.44 |
| ▸ | CLK2 | P49760 | 8/20 | 0.44 |
| ▸ | CLK3 | P49761 | 8/20 | 0.44 |
| ▸ | WNT1 | P04628 | 11/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12370070 | 0.91 | CLK2 (0.42) | DYRK1ACLK2CLK3WNT1TGFBR1 | |
| SCHEMBL12370053 | 0.90 | WNT1 (0.55) | DYRK1ACLK2CLK3WNT1TGFBR1 | |
| SCHEMBL12370060 | 0.90 | CLK2 (0.52) | DYRK1ACLK2CLK3WNT1TGFBR1 | |
| SCHEMBL12370075 | 0.90 | CLK2 (0.45) | DYRK1ACLK2CLK3WNT1TGFBR1 | |
| SCHEMBL12370073 | 0.89 | WNT1 (0.46) | DYRK1ACLK2CLK3WNT1TGFBR1 | |
| SCHEMBL12370065 | 0.88 | WNT1 (0.56) | DYRK1ACLK2CLK3WNT1TGFBR1 | |
| SCHEMBL19499882 | 0.88 | CLK2 (0.55) | DYRK1ACLK2CLK3WNT1TGFBR1 | |
| SCHEMBL20041368 | 0.88 | WNT1 (0.42) | DYRK1ACLK2CLK3WNT1TGFBR1 | |
| SCHEMBL12370064 | 0.88 | CLK2 (0.54) | DYRK1ACLK2CLK3WNT1TGFBR1 | |
| SCHEMBL12370068 | 0.87 | CLK2 (0.48) | DYRK1ACLK2CLK3WNT1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305073-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | Samumed, LLC (US) | 2018-04-11 | — | — | EP | disclosed |