Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 8/20 | 0.39 |
| ▸ | CLK2 | P49760 | 7/20 | 0.39 |
| ▸ | CLK3 | P49761 | 7/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12370051 | 0.89 | WNT1 (0.47) | WNT1CLK2CLK3DYRK1ATGFBR1 | |
| SCHEMBL12370101 | 0.82 | CLK2 (0.46) | WNT1CLK2CLK3DYRK1ATGFBR1 | |
| SCHEMBL12370048 | 0.81 | CLK2 (0.49) | WNT1CLK2CLK3DYRK1AAURKA | |
| SCHEMBL12370073 | 0.80 | WNT1 (0.46) | WNT1CLK2CLK3DYRK1ATGFBR1 | |
| SCHEMBL12370159 | 0.80 | WNT1 (0.46) | WNT1CLK2CLK3DYRK1ATGFBR1 | |
| SCHEMBL12370189 | 0.80 | CLK2 (0.45) | WNT1CLK2CLK3DYRK1ATGFBR1 | |
| SCHEMBL12370132 | 0.79 | CLK2 (0.47) | WNT1CLK2CLK3DYRK1ATGFBR1 | |
| SCHEMBL12370050 | 0.78 | WNT1 (0.54) | WNT1CLK2CLK3DYRK1ATGFBR1 | |
| SCHEMBL12395479 | 0.78 | WNT1 (0.46) | WNT1CLK2CLK3DYRK1ATGFBR1 | |
| SCHEMBL12370300 | 0.78 | CLK2 (0.53) | WNT1CLK2CLK3DYRK1ATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305073-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | Samumed, LLC (US) | 2018-04-11 | — | — | EP | disclosed |