Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27080410 | 1.00 | LMNA (0.36) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30178826 | 1.00 | LMNA (0.36) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL27080411 | 1.00 | LMNA (0.36) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21405088 | 1.00 | LMNA (0.36) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29984888 | 1.00 | LMNA (0.36) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29838208 | 1.00 | LMNA (0.36) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21405086 | 1.00 | LMNA (0.36) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21459051 | 1.00 | LMNA (0.36) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21459049 | 1.00 | LMNA (0.36) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29138197 | 0.89 | CYP2D6 (0.43) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960365-B2 | Compounds with medicinal effects due to interaction with the glucocorticoid receptor | N.V. ORGANON (NL) | 2011-06-14 | — | — | US | disclosed |