Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 10/20 | 0.54 |
| ▸ | ORAI1 | Q96D31 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1897432 | 0.89 | CRACR2A (0.68) | CRACR2AORAI1KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL1889277 | 0.88 | CRACR2A (0.67) | CRACR2AORAI1KDM4EALDH1A1HPGD | |
| SCHEMBL12661319 | 0.79 | CRACR2A (0.54) | CRACR2AORAI1KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL1668853 | 0.79 | CRACR2A (0.55) | CRACR2AORAI1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12673221 | 0.77 | CRACR2A (0.70) | CRACR2AORAI1 | |
| Hydrochloric Acid SCHEMBL1668162 | 0.77 | CRACR2A (0.69) | CRACR2AORAI1 | |
| SCHEMBL20006292 | 0.71 | CRACR2A (0.60) | CRACR2AORAI1KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL1671387 | 0.70 | CRACR2A (1.00) | CRACR2AORAI1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1667970 | 0.69 | CRACR2A (1.00) | CRACR2AORAI1 | |
| Hydrochloric Acid SCHEMBL1668858 | 0.69 | CRACR2A (0.44) | CRACR2AORAI1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509974-B1 | PYRAZOLES DERIVATIVES MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL AND METHODS FOR TREATMENT OF NON-SMALL CELL LUNG CANCER | RHIZEN PHARMACEUTICALS S A (CH) | 2018-04-11 | — | — | EP | disclosed |