Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PDE4A | P27815 | 4/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19559408 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL19559539 | 0.84 | FPR1 (0.53) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL19559566 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL19559404 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL13532862 | 0.81 | HPGD (0.69) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10762307 | 0.81 | HPGD (0.69) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL19559517 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6558457 | 0.80 | PDE4A (0.66) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18117748 | 0.80 | PDE4A (0.66) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28949764 | 0.79 | HPGD (0.74) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305763-A1 | DEUTERATED OR ISOTOPICALLY LABELED UREA DERIVATIVES OR PHARMACOLOGICALLY ACCEPTABLE SALTS THEREOF USEFUL AS FPRL-1 AGONISTS | Kyorin Pharmaceutical Co., Ltd. (JP) | 2018-04-11 | — | — | EP | disclosed |