Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TNF | P01375 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29010753 | 0.90 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1KMT2AALDH1A1TNF | |
| SCHEMBL21062982 | 0.88 | NPC1 (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1TNF | |
| SCHEMBL20043413 | 0.86 | CYP2C9 (0.42) | SMN1; SMN2MEN1KMT2AALDH1A1TNF | |
| SCHEMBL20031462 | 0.85 | ALDH1A1 (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1TNF | |
| SCHEMBL19899880 | 0.82 | NOTUM (0.42) | SMN1; SMN2MEN1KMT2AALDH1A1TNF | |
| SCHEMBL20833630 | 0.81 | NPC1 (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1TNF | |
| SCHEMBL19900083 | 0.81 | KMT2A (0.42) | SMN1; SMN2MEN1KMT2AALDH1A1TNF | |
| SCHEMBL2275524 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2AALDH1A1TNF | |
| SCHEMBL29163110 | 0.79 | SMN1; SMN2 (0.35) | SMN1; SMN2MEN1KMT2AALDH1A1TNF | |
| SCHEMBL29163112 | 0.79 | SMN1; SMN2 (0.35) | SMN1; SMN2MEN1KMT2AALDH1A1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180099957-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-04-12 | — | — | US | disclosed |
| WO-2018067704-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180099957-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | GPBAR1, SLC10A1, NR1H4 | SMN1; SMN2 4455/4885MEN1 4358/4885KMT2A 4512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.