Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006745 | 0.92 | LMNA (0.61) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL2003857 | 0.91 | KMT2A (0.55) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL2004167 | 0.91 | MEN1 (0.54) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL2007924 | 0.88 | LMNA (0.50) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL2006972 | 0.88 | LMNA (0.55) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL2002680 | 0.87 | LMNA (0.51) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL2007133 | 0.85 | MAPT (0.61) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL2004215 | 0.84 | LMNA (0.52) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL2005499 | 0.84 | MEN1 (0.52) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL1998366 | 0.84 | LMNA (0.48) | KMT2AMEN1LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |