Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1995977 | 0.85 | NR1H2 (0.55) | ALDH1A1KDM4EATMNPSR1TDP1 | |
| SCHEMBL377869 | 0.81 | KDM4E (0.53) | KCNJ1ALDH1A1KDM4ETDP1HTT | |
| SCHEMBL377528 | 0.81 | KDM4E (0.53) | KCNJ1ALDH1A1KDM4ETDP1HTT | |
| SCHEMBL27088090 | 0.76 | NR1H2 (0.43) | KCNJ1ALDH1A1KDM4ENPSR1NR1H2 | |
| SCHEMBL1420633 | 0.76 | NR1H2 (0.49) | KCNJ1ALDH1A1KDM4ENR1H2MEN1 | |
| SCHEMBL588829 | 0.76 | NR1H2 (0.62) | ALDH1A1KDM4ENR1H2KITSMN1; SMN2 | |
| SCHEMBL2849484 | 0.76 | MGLL (0.49) | KCNJ1ALDH1A1KDM4EATMNPSR1 | |
| SCHEMBL2849487 | 0.76 | MGLL (0.49) | KCNJ1ALDH1A1KDM4EATMNPSR1 | |
| SCHEMBL3554138 | 0.75 | KDM4E (0.39) | KCNJ1ALDH1A1KDM4ENPSR1TDP1 | |
| SCHEMBL28291908 | 0.75 | NR1H2 (0.39) | KCNJ1ALDH1A1KDM4ENR1H2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |