Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.36 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3019610 | 0.89 | CACNA1B (0.43) | KMT2AKDM4EMAPTCACNA1BAPBA1 | |
| SCHEMBL3019605 | 0.89 | CACNA1B (0.43) | KMT2AKDM4EMAPTCACNA1BAPBA1 | |
| SCHEMBL3019608 | 0.89 | CACNA1B (0.43) | KMT2AKDM4EMAPTCACNA1BAPBA1 | |
| SCHEMBL19450260 | 0.89 | CACNA1B (0.43) | KMT2AKDM4ELMNAMAPTMAPK1 | |
| SCHEMBL3024837 | 0.77 | NR4A1 (0.40) | KMT2AKDM4EMAPTSMN1; SMN2NR4A1 | |
| SCHEMBL3024833 | 0.77 | NR4A1 (0.40) | KMT2AKDM4EMAPTSMN1; SMN2NR4A1 | |
| SCHEMBL3024838 | 0.77 | NR4A1 (0.40) | KMT2AKDM4EMAPTSMN1; SMN2NR4A1 | |
| SCHEMBL3012222 | 0.77 | RAB9A (0.44) | KMT2AMAPTSMN1; SMN2POLBMEN1 | |
| SCHEMBL3012218 | 0.77 | RAB9A (0.44) | KMT2AMAPTSMN1; SMN2POLBMEN1 | |
| SCHEMBL3012216 | 0.77 | RAB9A (0.44) | KMT2AMAPTSMN1; SMN2POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067946-A1 | METHODS OF TREATING PATIENTS WITH A RETINOIC ACID RECEPTOR-ALPHA AGONIST AND AN ANTI-CD38 ANTIBODY | SYROS PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |