Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24603057 | 0.80 | HSD17B10 (0.40) | NR4A2ALDH1A1GAANOTUMHSD17B10 | |
| SCHEMBL18830048 | 0.80 | NR4A2 (0.38) | NR4A2ALDH1A1GAANOTUMHSD17B10 | |
| SCHEMBL21509656 | 0.80 | NR4A2 (0.38) | NR4A2ALDH1A1GAANOTUMHSD17B10 | |
| SCHEMBL38663430 | 0.78 | KDM4E (0.44) | NR4A2ALDH1A1GAAHSD17B10KDM4E | |
| SCHEMBL21200490 | 0.78 | SLC6A3 (0.39) | NR4A2ALDH1A1GAANOTUMHSD17B10 | |
| SCHEMBL30900389 | 0.78 | SLC6A3 (0.39) | NR4A2ALDH1A1GAANOTUMHSD17B10 | |
| SCHEMBL23704924 | 0.78 | KDM4E (0.44) | NR4A2ALDH1A1GAAHSD17B10KDM4E | |
| SCHEMBL23090012 | 0.78 | HPGD (0.41) | NR4A2ALDH1A1GAANOTUMHSD17B10 | |
| SCHEMBL24603091 | 0.78 | HSD17B10 (0.46) | NR4A2ALDH1A1GAANOTUMHSD17B10 | |
| SCHEMBL21199520 | 0.78 | NOTUM (0.40) | NR4A2ALDH1A1GAANOTUMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068017-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF RAS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC (US) | 2018-04-12 | — | — | WO | disclosed |