Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.36 |
| ▸ | CHUK | O15111 | 3/20 | 0.36 |
| ▸ | DHODH | Q02127 | 4/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004643 | 0.74 | PARP1 (0.35) | DHODHCDK2CDC7CCNE1DBF4 | |
| SCHEMBL28156921 | 0.70 | FGFR1 (0.62) | IKBKBFGFR1KDRKMT2AHASPIN | |
| SCHEMBL28156867 | 0.68 | TNF (0.44) | IKBKBCHUKROCK1FGFR1MAPK1 | |
| SCHEMBL8169066 | 0.66 | MAPT (0.58) | KMT2A | |
| SCHEMBL20553500 | 0.65 | MAPT (0.41) | DHODHSLC22A12KMT2A | |
| SCHEMBL28187425 | 0.65 | TNF (0.41) | IKBKBCHUKROCK1FGFR1MAPK1 | |
| SCHEMBL1339563 | 0.65 | DHODH (0.52) | DHODHCDC7DBF4 | |
| SCHEMBL10837807 | 0.64 | FGFR1 (0.49) | IKBKBFGFR1CHEK2KMT2ASRC | |
| SCHEMBL5717596 | 0.64 | KDM4E (0.44) | IKBKBCHUKCDC7ROCK1FGFR1 | |
| SCHEMBL1501769 | 0.63 | AKT1 (0.48) | IKBKBDHODHSLC22A12AKT1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075383-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |