Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFB2 | P61812 | 1/20 | 0.55 |
| ▸ | ACVR1 | Q04771 | 11/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.48 |
| ▸ | BMP4 | P12644 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 4/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 4/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18155042 | 0.93 | TGFB2 (0.64) | TGFB2ACVR1TGFBR1AURKATTK | |
| SCHEMBL18163940 | 0.90 | PDGFRB (0.51) | TGFB2ACVR1TGFBR1AURKATTK | |
| SCHEMBL18155091 | 0.90 | FGFR1 (0.50) | TGFB2ACVR1TGFBR1AURKATTK | |
| SCHEMBL18155078 | 0.87 | TGFB2 (0.52) | TGFB2AURKAAURKBINCENPPIM1 | |
| SCHEMBL18163943 | 0.86 | TGFB2 (0.57) | TGFB2ACVR1BMPR1BACVRL1KDR | |
| SCHEMBL18155095 | 0.85 | TGFB2 (0.51) | TGFB2ACVR1KDRPIM1PIM3 | |
| SCHEMBL18155106 | 0.85 | TGFB2 (0.52) | TGFB2ACVR1TGFBR1BMP4BMPR1B | |
| SCHEMBL18155045 | 0.84 | FGFR1 (0.54) | TGFB2ACVR1TGFBR1AURKATTK | |
| SCHEMBL18155028 | 0.84 | TGFB2 (0.49) | TGFB2AURKAAURKBINCENPFLT3 | |
| SCHEMBL18164050 | 0.83 | TGFB2 (0.58) | TGFB2AURKAAURKBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283475-B1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-10-16 | — | — | EP | disclosed |
| US-10179777-B2 | 3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one derivatives | MERCK PATENT GMBH (DE) | 2019-01-15 | — | — | US | disclosed |
| US-20180099947-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10179777-B2 | 3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one derivatives | ALK, ABL2, ACVR1 | TGFB2 267/4885ACVR1 3/4885TGFBR1 30/4885 |
| US-20180099947-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | ALK, ABL2, ACVR1 | TGFB2 267/4885ACVR1 3/4885TGFBR1 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.