Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.54 |
| ▸ | FLT1 | P17948 | 5/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.54 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.54 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.54 |
| ▸ | CBFB | Q13951 | 1/20 | 0.53 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18163940 | 0.94 | PDGFRB (0.51) | FGFR1FLT1PDGFRBKDRACVR1B | |
| SCHEMBL18155042 | 0.91 | TGFB2 (0.64) | FGFR1FLT1PDGFRBKDRACVR1B | |
| SCHEMBL20048367 | 0.84 | TGFB2 (0.55) | FGFR1PDGFRBKDRACVR1BTGFBR1 | |
| SCHEMBL18155091 | 0.83 | FGFR1 (0.50) | FGFR1FLT1PDGFRBKDRACVR1B | |
| SCHEMBL18155092 | 0.83 | NPC1 (0.66) | FGFR1FLT1PDGFRBKDRACVR1 | |
| SCHEMBL18155104 | 0.81 | RHEB (0.45) | FGFR1FLT1PDGFRBKDRCBFB | |
| SCHEMBL18155103 | 0.78 | SYK (0.51) | FGFR1FLT1PDGFRBKDRTGFB2 | |
| SCHEMBL18155098 | 0.78 | TGFB2 (0.67) | FGFR1FLT1PDGFRBKDRTGFB2 | |
| SCHEMBL18155107 | 0.77 | DYRK1A (0.46) | BMPR1BBMPR1AACVRL1ACVR1TGFB2 | |
| SCHEMBL30424336 | 0.75 | FGFR1 (0.65) | FGFR1FLT1PDGFRBKDRCBFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283475-B1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-10-16 | — | — | EP | claimed |
| EP-3283475-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016165808-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | WO | disclosed |