Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049119 | 0.83 | KCNH2 (0.34) | KCNH2HRH4HRH3HRH2HRH1 | |
| SCHEMBL20048949 | 0.73 | KCNH2 (0.31) | KCNH2HRH4HRH3 | |
| SCHEMBL20675598 | 0.71 | CCR1 (0.46) | KCNH2 | |
| Ethoxycarbonyl Group SCHEMBL28040584 | 0.71 | — | — | |
| SCHEMBL20049379 | 0.71 | — | — | |
| SCHEMBL30900020 | 0.70 | NPC1 (0.41) | HRH4 | |
| SCHEMBL20049186 | 0.70 | NPC1 (0.41) | HRH4 | |
| SCHEMBL103875 | 0.66 | ALDH1A1 (0.42) | CYP11B1CYP11B2 | |
| SCHEMBL24019244 | 0.66 | HSD17B10 (0.34) | — | |
| SCHEMBL18876144 | 0.66 | MEN1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067704-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |