Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30134126 | 0.81 | CYP1A2 (0.39) | PDE10AOGACYP1A2CYP2C9HIF1A | |
| SCHEMBL14084761 | 0.77 | PDE10A (0.42) | PDE10ANPC1RAB9ASCN4ASMN1; SMN2 | |
| SCHEMBL10272989 | 0.77 | NQO2 (0.47) | PDE10ANPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL682228 | 0.77 | NPC1 (0.49) | NPC1RAB9ASCN4ASMN1; SMN2HIF1A | |
| SCHEMBL13677497 | 0.77 | NPC1 (0.41) | PDE10ANPC1RAB9ASCN4ASMN1; SMN2 | |
| SCHEMBL20049295 | 0.77 | NPC1 (0.41) | PDE10ANPC1RAB9ASCN4ASMN1; SMN2 | |
| SCHEMBL18948584 | 0.76 | PDE10A (0.53) | PDE10ANPC1RAB9ASCN4ASMN1; SMN2 | |
| SCHEMBL13226945 | 0.76 | PABPC1 (0.41) | PDE10ACYP1A2CYP2C9HIF1AKMT2A | |
| SCHEMBL10271340 | 0.76 | HRH4 (0.51) | PDE10ACYP1A2KMT2AMEN1MAPT | |
| SCHEMBL12938128 | 0.73 | NPC1 (0.50) | NPC1RAB9ASCN4ASMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067704-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |