Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14970054 | 0.72 | HSD17B10 (0.33) | — | |
| SCHEMBL6466753 | 0.71 | NOS3 (0.40) | NOS3NOS1NOS2 | |
| SCHEMBL31696345 | 0.69 | USP2 (0.32) | — | |
| SCHEMBL7990997 | 0.69 | USP2 (0.32) | — | |
| SCHEMBL1673946 | 0.69 | USP2 (0.32) | — | |
| SCHEMBL31374320 | 0.69 | NOS3 (0.41) | NOS3NOS1NOS2 | |
| SCHEMBL9953928 | 0.69 | NOS3 (0.41) | NOS3NOS1NOS2 | |
| SCHEMBL23643784 | 0.67 | POLB (0.41) | — | |
| SCHEMBL16268335 | 0.67 | USP2 (0.33) | — | |
| SCHEMBL6844986 | 0.67 | KDM4E (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067704-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |