Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 15/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.41 |
| ▸ | METTL3 | Q86U44 | 5/20 | 0.40 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049551 | 0.89 | NPC1 (0.39) | PRMT5WDR77 | |
| SCHEMBL23892234 | 0.81 | PRMT5 (0.59) | PRMT5WDR77METTL3 | |
| SCHEMBL18572040 | 0.81 | PRMT5 (0.47) | PRMT5WDR77METTL3 | |
| SCHEMBL20049645 | 0.80 | PRMT5 (0.66) | PRMT5WDR77METTL3 | |
| SCHEMBL23892222 | 0.77 | PRMT5 (0.59) | PRMT5WDR77METTL3MEN1 | |
| SCHEMBL24067861 | 0.77 | PRMT5 (0.54) | PRMT5WDR77METTL3 | |
| SCHEMBL20049543 | 0.76 | PRMT5 (0.47) | PRMT5WDR77METTL3 | |
| SCHEMBL25047848 | 0.76 | ADK (0.50) | PRMT5WDR77METTL3ADCY5MEN1 | |
| SCHEMBL10293819 | 0.76 | MEN1 (0.47) | PRMT5WDR77METTL3ADCY5MEN1 | |
| SCHEMBL19344041 | 0.75 | ADCY5 (0.47) | PRMT5WDR77METTL3ADCY5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018065365-A1 | NOVEL MONOCYCLIC AND BICYCLIC RING SYSTEM SUBSTITUTED CARBANUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |