Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.35 |
| ▸ | LPL | P06858 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16397840 | 0.80 | AAK1 (0.46) | PRMT5WDR77AAK1P4HBLIPG | |
| SCHEMBL16113078 | 0.77 | SLC7A5 (0.43) | PRMT5WDR77AAK1P4HBLIPG | |
| SCHEMBL29661903 | 0.77 | SLC7A5 (0.43) | PRMT5WDR77AAK1P4HBLIPG | |
| SCHEMBL3321408 | 0.75 | PRMT5 (0.49) | PRMT5WDR77AAK1DGAT1SMN1; SMN2 | |
| SCHEMBL3800262 | 0.74 | AAK1 (0.49) | PRMT5WDR77AAK1MAPK10LIPG | |
| SCHEMBL29539567 | 0.74 | AAK1 (0.49) | PRMT5WDR77AAK1MAPK10LIPG | |
| SCHEMBL1300326 | 0.74 | PRMT5 (0.47) | PRMT5WDR77AAK1HIF1AHDAC3 | |
| SCHEMBL29895473 | 0.74 | PRMT5 (0.47) | PRMT5WDR77AAK1HIF1AHDAC3 | |
| SCHEMBL24213545 | 0.71 | HDAC1 (0.42) | AAK1MAPK10MAPTHDAC1HDAC6 | |
| SCHEMBL2592478 | 0.71 | PRMT5 (0.57) | PRMT5WDR77AAK1LIPGLPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523291-B1 | CYANO-SUBSTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LTD (GB) | 2021-04-14 | — | — | EP | disclosed |
| WO-2018065768-A1 | CYANO-SUBSTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2018-04-12 | — | — | WO | disclosed |