Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006480 | 0.91 | LMNA (0.48) | LMNASMN1; SMN2HDAC1HDAC2HDAC6 | |
| SCHEMBL2002672 | 0.89 | LMNA (0.48) | LMNASMN1; SMN2HDAC1HDAC2HDAC6 | |
| SCHEMBL2004265 | 0.89 | LMNA (0.55) | LMNASMN1; SMN2HDAC1HDAC2HDAC6 | |
| SCHEMBL2004269 | 0.88 | LMNA (0.48) | LMNASMN1; SMN2HDAC1HDAC2HDAC6 | |
| SCHEMBL2004469 | 0.88 | LMNA (0.45) | LMNASMN1; SMN2HDAC1HDAC2HDAC6 | |
| SCHEMBL2003695 | 0.87 | LMNA (0.47) | LMNASMN1; SMN2HDAC1HDAC2HDAC6 | |
| SCHEMBL2007306 | 0.86 | LMNA (0.47) | LMNASMN1; SMN2HDAC1HDAC2HDAC6 | |
| SCHEMBL2002459 | 0.86 | LMNA (0.52) | LMNASMN1; SMN2HDAC1HDAC2HDAC6 | |
| SCHEMBL2004530 | 0.86 | LMNA (0.48) | LMNASMN1; SMN2HDAC1HDAC2HDAC6 | |
| SCHEMBL2006666 | 0.86 | LMNA (0.48) | LMNASMN1; SMN2HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |