Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 3/20 | 0.67 |
| ▸ | KDR | P35968 | 10/20 | 0.62 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.62 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.62 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.59 |
| ▸ | LCK | P06239 | 3/20 | 0.59 |
| ▸ | FYN | P06241 | 3/20 | 0.59 |
| ▸ | CSF1R | P07333 | 3/20 | 0.59 |
| ▸ | RET | P07949 | 3/20 | 0.59 |
| ▸ | PHKG2 | P15735 | 3/20 | 0.59 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.59 |
| ▸ | AXL | P30530 | 3/20 | 0.59 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.59 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.59 |
| ▸ | FLT1 | P17948 | 3/20 | 0.59 |
| ▸ | PLK4 | O00444 | 2/20 | 0.59 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14519116 | 0.86 | RET (0.62) | ALKKDRPRKAA1PDGFRBFGFR1 | |
| SCHEMBL6857967 | 0.86 | KDR (0.74) | ALKKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL5370172 | 0.86 | KDR (0.59) | ALKKDRPRKAA1PDGFRBFGFR1 | |
| SCHEMBL6857969 | 0.86 | KDR (0.74) | ALKKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL13799829 | 0.85 | AURKA (0.68) | ALKKDRPRKAA1PRKAA2TLK2 | |
| SCHEMBL18814391 | 0.84 | ALK (0.71) | ALKKDRPRKAA1PRKAA2TLK2 | |
| SCHEMBL14854970 | 0.83 | ALK (0.70) | ALKKDRPRKAA1PRKAA2TLK2 | |
| SCHEMBL14864965 | 0.83 | ALK (0.64) | ALKKDRPRKAA1PRKAA2TLK2 | |
| SCHEMBL5728020 | 0.83 | PDGFRB (0.81) | ALKKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL5728018 | 0.83 | PDGFRB (0.81) | ALKKDRPRKAA1PRKAA2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180185496-A1 | POLYMER-SEMAXANIB MOIETY CONJUGATES | NEKTAR THERAPEUTICS | 2018-07-05 | — | — | US | disclosed |
| US-9943605-B2 | Polymer-semaxanib moiety conjugates | NEKTAR THERAPEUTICS (US) | 2018-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180185496-A1 | POLYMER-SEMAXANIB MOIETY CONJUGATES | FLT4, TEK, GLP1R | ALK 453/4885KDR 14/4885PRKAA1 4853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.