Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.68 |
| ▸ | KDR | P35968 | 12/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 12/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.66 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.62 |
| ▸ | RET | P07949 | 4/20 | 0.62 |
| ▸ | FLT1 | P17948 | 3/20 | 0.62 |
| ▸ | FLT3 | P36888 | 3/20 | 0.62 |
| ▸ | STK3 | Q13188 | 3/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.62 |
| ▸ | LCK | P06239 | 3/20 | 0.62 |
| ▸ | CSF1R | P07333 | 3/20 | 0.62 |
| ▸ | PHKG2 | P15735 | 3/20 | 0.62 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.62 |
| ▸ | AXL | P30530 | 3/20 | 0.62 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.62 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.62 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12020869 | 0.85 | KDR (0.84) | AURKAKDRPDGFRBFGFR1ALK | |
| SCHEMBL20051937 | 0.85 | ALK (0.67) | AURKAKDRPDGFRBFGFR1ALK | |
| SCHEMBL13813174 | 0.83 | PDGFRB (0.59) | AURKAKDRPDGFRBFGFR1ALK | |
| SCHEMBL8210235 | 0.82 | ALK (0.83) | AURKAKDRPDGFRBFGFR1ALK | |
| SCHEMBL13960175 | 0.82 | PDGFRB (0.83) | AURKAKDRPDGFRBFGFR1ALK | |
| SCHEMBL4405035 | 0.81 | KDR (0.81) | AURKAKDRPDGFRBFGFR1ALK | |
| SCHEMBL4405036 | 0.81 | KDR (0.81) | AURKAKDRPDGFRBFGFR1ALK | |
| SCHEMBL3800157 | 0.81 | AURKA (1.00) | AURKAKDRPDGFRBFGFR1ALK | |
| SCHEMBL3800161 | 0.81 | AURKA (1.00) | AURKAKDRPDGFRBFGFR1ALK | |
| SCHEMBL18814394 | 0.81 | ALK (0.82) | AURKAKDRPDGFRBFGFR1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163371-A1 | Anchor-Assisted Fragment Selection and Directed Assembly | ENSEMBLE THERAPEUTICS CORPORATION | 2009-06-25 | — | — | US | disclosed |