Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.79 |
| ▸ | PRKAA1 | Q13131 | 8/20 | 0.79 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.79 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.79 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.75 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.75 |
| ▸ | PLK4 | O00444 | 2/20 | 0.75 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.75 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.75 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.75 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.75 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.75 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.75 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.75 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.75 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.75 |
| ▸ | INSR | P06213 | 2/20 | 0.75 |
| ▸ | LCK | P06239 | 2/20 | 0.75 |
| ▸ | FYN | P06241 | 2/20 | 0.75 |
| ▸ | FES | P07332 | 2/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20051940 | 0.92 | PRKAA1 (0.81) | KDRPRKAA1PRKAA2TLK2PDGFRB | |
| SCHEMBL14047978 | 0.90 | KDR (0.86) | KDRPRKAA1PRKAA2TLK2PDGFRB | |
| SCHEMBL29856566 | 0.90 | KDR (0.86) | KDRPRKAA1PRKAA2TLK2PDGFRB | |
| SCHEMBL29773949 | 0.90 | KDR (0.82) | KDRPRKAA1PRKAA2TLK2PDGFRB | |
| SCHEMBL2115189 | 0.88 | KDR (1.00) | KDRPRKAA1PRKAA2TLK2PDGFRB | |
| SCHEMBL4453225 | 0.88 | KDR (1.00) | KDRPRKAA1PRKAA2TLK2PDGFRB | |
| SCHEMBL29766479 | 0.88 | KDR (1.00) | KDRPRKAA1PRKAA2TLK2PDGFRB | |
| SCHEMBL28435599 | 0.88 | PRKAA1 (0.84) | KDRPRKAA1PRKAA2TLK2PDGFRB | |
| SCHEMBL28435601 | 0.88 | PRKAA1 (0.84) | KDRPRKAA1PRKAA2TLK2PDGFRB | |
| SCHEMBL28430885 | 0.88 | KDR (0.86) | KDRPRKAA1PRKAA2TLK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9943605-B2 | Polymer-semaxanib moiety conjugates | NEKTAR THERAPEUTICS (US) | 2018-04-17 | — | — | US | disclosed |