Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.81 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.81 |
| ▸ | KDR | P35968 | 9/20 | 0.80 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.80 |
| ▸ | PDGFRB | P09619 | 11/20 | 0.79 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.79 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.77 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.77 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.77 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.77 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.77 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.77 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.77 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.77 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.77 |
| ▸ | PLK4 | O00444 | 2/20 | 0.76 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.76 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20052474 | 0.92 | KDR (0.79) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL1626038 | 0.91 | PDGFRB (0.81) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL1626040 | 0.91 | PDGFRB (0.81) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL29856566 | 0.91 | KDR (0.86) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL28435601 | 0.91 | PRKAA1 (0.84) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL28435599 | 0.91 | PRKAA1 (0.84) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL14047978 | 0.91 | KDR (0.86) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL2115786 | 0.90 | KDR (0.84) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL28427292 | 0.90 | PRKAA1 (1.00) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL31672471 | 0.90 | KDR (0.84) | PRKAA1PRKAA2KDRTLK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180185496-A1 | POLYMER-SEMAXANIB MOIETY CONJUGATES | NEKTAR THERAPEUTICS | 2018-07-05 | — | — | US | disclosed |
| US-9943605-B2 | Polymer-semaxanib moiety conjugates | NEKTAR THERAPEUTICS (US) | 2018-04-17 | — | — | US | disclosed |
| US-9943605-B2 | Polymer-semaxanib moiety conjugates | NEKTAR THERAPEUTICS (US) | 2018-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180185496-A1 | POLYMER-SEMAXANIB MOIETY CONJUGATES | FLT4, TEK, GLP1R | PRKAA1 4853/4885PRKAA2 4840/4885KDR 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.