SCHEMBL2005375

SCHEMBL2005375

Cc1ccc(CNc2ccc(C)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.80
MEN1 O00255 4/20 0.80
KMT2A Q03164 4/20 0.80
L3MBTL1 Q9Y468 4/20 0.80
ALDH1A1 P00352 4/20 0.80
GAA P10253 3/20 0.80
HPGD P15428 3/20 0.80
MAPK1 P28482 3/20 0.80
CASP1 P29466 3/20 0.80
KDM4E B2RXH2 2/20 0.80
THRB P10828 2/20 0.80
POLB P06746 2/20 0.80
ALOX15 P16050 2/20 0.80
BLM P54132 2/20 0.80
HSD17B10 Q99714 2/20 0.80
HSP90AA1 P07900 1/20 0.80
HSP90AB1 P08238 1/20 0.80
PLEC Q15149 1/20 0.80
HTT P42858 2/20 0.79
RAB9A P51151 3/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10055032 1.00 MAPT (0.80) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL22783760 0.93 MAPT (0.71) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL22674849 0.91 MAPT (0.69) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL4592466 0.91 MAPT (0.69) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL6416118 0.89 MEN1 (0.67) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL19419957 0.89 MEN1 (0.67) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL171854 0.89 MAPT (0.67) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL11935858 0.89 MAPT (0.67) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL6414545 0.89 MAPT (0.67) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL14950714 0.89 MAPT (1.00) MAPTMEN1KMT2AL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115745808-B Method for preparing secondary amine compound by catalyzing reduction of imine compound 延安大学 2024-04-30 CN disclosed
CN-113861065-B Method for preparing asymmetric imine or asymmetric secondary amine compound by photocatalysis 苏州大学张家港工业技术研究院 2023-09-26 CN disclosed
US-11696937-B2 Glycopeptide compounds having activity of resisting drug-resistant bacteria, and preparation method and application thereof SHANGHAI LAIYI CENTER FOR BIOPHARMACEUTICAL R&D CO., LTD. (CN) 2023-07-11 US disclosed
US-11696937-B2 Glycopeptide compounds having activity of resisting drug-resistant bacteria, and preparation method and application thereof SHANGHAI LAIYI CENTER FOR BIOPHARMACEUTICAL R&D CO., LTD. (CN) 2023-07-11 US disclosed
CN-115745808-A Method for preparing secondary amine compound by catalyzing reduction of imine compound 延安大学 2023-03-07 CN disclosed
WO-2023003468-A1 NOVEL INHIBITORS OF HISTONE DEACETYLASE (HDAC), AND METHODS, COMPOSITIONS AND USES RELATED THERETO. RIJKSUNIVERSITEIT GRONINGEN (NL) 2023-01-26 WO disclosed
US-20210093691-A1 Glycopeptide Compounds Having Activity Of Resisting Drug-Resistant Bacteria, And Preparation Method And Application Thereof SHANGHAI LAIYI CENTER FOR BIOPHARMACEUTICAL R&D CO., LTD. (CN) 2021-04-01 US disclosed
EP-3763728-A1 GLYCOPEPTIDE COMPOUNDS HAVING ACTIVITY OF RESISTING DRUG-RESISTANT BACTERIA, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Shanghai LaiYi Center For Biopharmaceutical R&D Co., Ltd. (CN) 2021-01-13 EP disclosed
US-20180079962-A1 LIQUID CRYSTAL DISPLAY DEVICE AND MANUFACTURING METHOD THEREOF MAGNOLIA PURPLE CORPORATION (JP) 2018-03-22 US disclosed
US-9868907-B2 Liquid crystal display device and manufacturing method thereof JAPAN DISPLAY INC. (JP) 2018-01-16 US disclosed
US-9028926-B2 Liquid crystal display device and manufacturing method thereof JAPAN DISPLAY INC. (JP) 2015-05-12 US disclosed
US-20140046004-A1 LIQUID CRYSTAL DISPLAY DEVICE AND MANUFACTURING METHOD THEREOF JAPAN DISPLAY, INC. (JP) 2014-02-13 US disclosed
EP-1994004-B9 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS JANSSEN PHARMACEUTICALS INC (US) 2013-04-17 EP disclosed
US-7960435-B2 Anti-cancer agents and androgen inhibition activity compound UNIVERSITY OF MARYLAND, BALTIMORE (US) 2011-06-14 US disclosed
US-7960435-B2 Anti-cancer agents and androgen inhibition activity compound UNIVERSITY OF MARYLAND, BALTIMORE (US) 2011-06-14 US disclosed
US-20100113600-A1 ANTI-CANCER AGENTS AND ANDROGEN INHIBITION ACTIVITY COMPOUND UNIVERSITY OF MARYLAND, BALTIMORE (US) 2010-05-06 US disclosed
US-20100113600-A1 ANTI-CANCER AGENTS AND ANDROGEN INHIBITION ACTIVITY COMPOUND UNIVERSITY OF MARYLAND, BALTIMORE (US) 2010-05-06 US disclosed
US-20090053430-A1 Liquid Crystal Display Device and Manufacturing Method Thereof HITACHI DISPLAYS. LTD. 2009-02-26 US disclosed
WO-2008076918-A9 ANTI-CANCER AGENTS AND ANDROGEN INHIBITION ACTIVITY COMPOUND UNIV MARYLAND (US) 2008-08-07 WO disclosed
WO-2008076918-A2 ANTI-CANCER AGENTS AND ANDROGEN INHIBITION ACTIVITY COMPOUND UNIVERSITY OF MARYLAND, BALTIMORE (US) 2008-06-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210093691-A1 Glycopeptide Compounds Having Activity Of Resisting Drug-Resistant Bacteria, And Preparation Method And Application Thereof VIP, CUTA, MGAM MAPT 3389/4885MEN1 3260/4885KMT2A 4167/4885
US-11696937-B2 Glycopeptide compounds having activity of resisting drug-resistant bacteria, and preparation method and application thereof VIP, CUTA, MGAM MAPT 3389/4885MEN1 3260/4885KMT2A 4167/4885
US-20100113600-A1 ANTI-CANCER AGENTS AND ANDROGEN INHIBITION ACTIVITY COMPOUND AR, HTR3D, NR5A1 MAPT 4558/4885MEN1 2290/4885KMT2A 1411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.