Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 8/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20053949 | 0.86 | BTK (0.47) | DYRK1AJAK2AKT3BTK | |
| SCHEMBL20053967 | 0.82 | BTK (0.50) | AKT3BTKCTSA | |
| SCHEMBL16794277 | 0.82 | BTK (0.51) | MAPK1JAK2BTKMAPK3 | |
| SCHEMBL20053939 | 0.75 | BTK (0.47) | AKT3BTK | |
| SCHEMBL16793892 | 0.73 | BTK (0.58) | JAK2BTK | |
| SCHEMBL20461131 | 0.71 | BTK (0.38) | DYRK1ABTKCDK2 | |
| SCHEMBL16794439 | 0.70 | BTK (0.63) | AKT3BTK | |
| SCHEMBL26073236 | 0.68 | AAK1 (0.38) | BTK | |
| SCHEMBL20461218 | 0.68 | BTK (0.40) | DYRK1AJAK2BTK | |
| SCHEMBL16793657 | 0.68 | MAPK1 (0.37) | MAPK1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080103-B1 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | BIOGEN MA INC (US) | 2018-04-18 | — | — | EP | disclosed |