Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 2/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 5/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 4/20 | 0.35 |
| ▸ | JAK3 | P52333 | 5/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20054019 | 0.87 | IKBKE (0.43) | IKBKETBK1CCNT1CCNE1CDK2 | |
| SCHEMBL16794044 | 0.83 | IKBKE (0.49) | IKBKETBK1CCNT1CCNE1CDK2 | |
| SCHEMBL20054057 | 0.81 | BTK (0.37) | BTK | |
| SCHEMBL16794039 | 0.79 | BTK (0.45) | IKBKETBK1CCNT1CCNE1CDK2 | |
| SCHEMBL16794380 | 0.79 | IKBKE (0.51) | IKBKETBK1CCNT1CCNE1CDK2 | |
| SCHEMBL16794467 | 0.79 | IKBKE (0.44) | IKBKETBK1CCNT1CCNE1CDK2 | |
| SCHEMBL16794198 | 0.79 | BTK (0.65) | IKBKETBK1CCNT1CCNE1CDK2 | |
| SCHEMBL20445711 | 0.78 | IKBKE (0.48) | IKBKETBK1CCNT1CCNE1CDK2 | |
| SCHEMBL29676766 | 0.78 | IKBKE (0.48) | IKBKETBK1CCNT1CCNE1CDK2 | |
| SCHEMBL19557886 | 0.78 | IKBKE (0.60) | IKBKETBK1CCNT1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357921-A2 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | Sunesis Pharmaceuticals, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-3080103-B1 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | BIOGEN MA INC (US) | 2018-04-18 | — | — | EP | disclosed |