Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8229096 | 0.77 | MEN1 (0.48) | SLC6A4ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL22876868 | 0.76 | SLC6A4 (0.50) | SLC6A4MAOAMAOBTAAR1TSHR | |
| SCHEMBL19402984 | 0.75 | MAOA (0.54) | SLC6A4MAOAMAOBTAAR1CHRM2 | |
| SCHEMBL1409709 | 0.75 | SLC6A4 (0.81) | SLC6A4MAOAMAOBTAAR1SLC6A2 | |
| SCHEMBL13573944 | 0.72 | MAOA (0.50) | SLC6A4MAOAMAOBTAAR1CHRM2 | |
| SCHEMBL8223421 | 0.71 | MEN1 (0.55) | SLC6A4TSHRHTTCHRM2CHRM1 | |
| SCHEMBL13539472 | 0.70 | SLC6A4 (0.58) | SLC6A4MAOAMAOBTAAR1TSHR | |
| SCHEMBL16839035 | 0.68 | GAA (0.48) | SLC6A4TSHRHTTCHRM2CHRM1 | |
| SCHEMBL12745074 | 0.68 | SLC6A4 (0.89) | SLC6A4DPP4SLC6A2SLC6A3LMNA | |
| SCHEMBL14359682 | 0.68 | DPP4 (0.52) | SLC6A4MAOAMAOBTAAR1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3327027-A1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | Pfizer Inc (US) | 2018-05-30 | — | — | EP | disclosed |
| EP-2780039-B9 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2018-04-18 | — | — | EP | disclosed |