Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.58 |
| ▸ | MGLL | Q99685 | 6/20 | 0.58 |
| ▸ | FAAH | O00519 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20151749 | 0.87 | MGLL (0.64) | PTGS1PTGS2MGLLFAAHEPHX2 | |
| SCHEMBL20196417 | 0.84 | PTGS1 (0.57) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL28348837 | 0.84 | PTGS1 (0.58) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL20151753 | 0.83 | MGLL (0.62) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL30373706 | 0.82 | PTGS1 (0.50) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL21909660 | 0.82 | PTGS1 (0.64) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL29047113 | 0.81 | PTGS1 (0.65) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL13828051 | 0.79 | PTGS1 (0.45) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL15254653 | 0.79 | EPHX2 (0.62) | ALDH1A1SMN1; SMN2EPHX2BCHEACHE | |
| SCHEMBL16781560 | 0.79 | PTGS1 (0.47) | PTGS1PTGS2MGLLFAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B9 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2018-04-18 | — | — | EP | disclosed |