Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2707231 | 0.87 | KIF11 (0.62) | KIF11MAPTAURKADAPK3JAK2 | |
| SCHEMBL19608621 | 0.83 | KIF11 (0.56) | KIF11MAPTAURKADAPK3JAK2 | |
| SCHEMBL13560650 | 0.83 | KIF11 (0.61) | KIF11KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL9980170 | 0.81 | MEN1 (0.58) | KIF11AURKADAPK3JAK2MAP4K4 | |
| SCHEMBL12789481 | 0.79 | KIF11 (0.65) | KIF11KDM4ENPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL13071245 | 0.78 | NPC1 (0.58) | KIF11MAPTKDM4ENPC1ALDH1A1 | |
| SCHEMBL14985632 | 0.78 | MEN1 (0.62) | KIF11TP53MAPTAURKADAPK3 | |
| SCHEMBL14922493 | 0.77 | KIF11 (0.66) | KIF11KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL10063356 | 0.74 | KDM4E (0.47) | KIF11TP53MAPTAURKADAPK3 | |
| SCHEMBL5866556 | 0.74 | KDM4E (0.47) | KIF11TP53MAPTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3309157-A1 | ANTIVIRAL COMPOUNDS | Gilead Pharmasset LLC (US) | 2018-04-18 | — | — | EP | disclosed |