Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 16/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.62 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26082773 | 0.85 | CACNA1I (0.72) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL20056313 | 0.84 | CACNA1I (0.62) | CACNA1IKCNH2CACNA1HCACNA1GPOLB | |
| SCHEMBL26082093 | 0.84 | CACNA1I (0.84) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL19113212 | 0.84 | KCNH2 (0.59) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL14763517 | 0.83 | CACNA1I (0.67) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL4280786 | 0.83 | CACNA1I (0.63) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL4277996 | 0.82 | KCNH2 (0.56) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL14708784 | 0.82 | CACNA1I (0.59) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL8374124 | 0.82 | KCNH2 (0.59) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL4275757 | 0.81 | KCNH2 (0.55) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |