Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 11/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.47 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19112534 | 0.89 | CACNA1I (0.65) | CACNA1IKCNH2GSK3BADCY8ADCY1 | |
| SCHEMBL13569699 | 0.87 | KCNH2 (0.63) | CACNA1IKCNH2GSK3BADCY8ADCY1 | |
| SCHEMBL19113048 | 0.86 | KCNH2 (0.62) | CACNA1IKCNH2GSK3BADCY8ADCY1 | |
| SCHEMBL4278216 | 0.86 | KCNH2 (0.64) | CACNA1IKCNH2GSK3BHTR4CACNA1H | |
| SCHEMBL4275269 | 0.86 | CACNA1I (0.64) | CACNA1IKCNH2GSK3BCACNA1HCACNA1G | |
| SCHEMBL19113054 | 0.85 | TDP1 (0.59) | CACNA1IKCNH2ADCY8ADCY1CACNA1H | |
| SCHEMBL19112469 | 0.85 | KCNH2 (0.60) | CACNA1IKCNH2GSK3BADCY8ADCY1 | |
| SCHEMBL20056147 | 0.84 | CACNA1I (0.62) | CACNA1IKCNH2CACNA1HPOLBKMT2A | |
| SCHEMBL4276558 | 0.84 | CACNA1I (0.64) | CACNA1IKCNH2GSK3BHTR4CACNA1H | |
| SCHEMBL4280376 | 0.84 | KCNH2 (0.59) | CACNA1IKCNH2GSK3BADCY8ADCY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |