Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 15/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.65 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22019442 | 0.95 | CACNA1I (0.71) | CACNA1IKCNH2CACNA1HCYP2D6MEN1 | |
| SCHEMBL19112854 | 0.92 | CACNA1I (0.54) | CACNA1IKCNH2CACNA1HCYP2D6MEN1 | |
| SCHEMBL19112685 | 0.92 | CACNA1I (0.66) | CACNA1IKCNH2CACNA1HCYP2D6MEN1 | |
| SCHEMBL20056295 | 0.90 | CACNA1I (0.63) | CACNA1IKCNH2CACNA1HCYP2D6MEN1 | |
| SCHEMBL4276378 | 0.87 | CACNA1I (0.72) | CACNA1IKCNH2CACNA1HCYP2D6MEN1 | |
| SCHEMBL13569793 | 0.85 | CACNA1I (0.70) | CACNA1IKCNH2CACNA1HCYP2D6MEN1 | |
| SCHEMBL4272178 | 0.83 | CACNA1I (0.77) | CACNA1IKCNH2CACNA1HCYP2D6MEN1 | |
| SCHEMBL4274781 | 0.83 | CACNA1I (0.75) | CACNA1IKCNH2CACNA1HCYP2D6MEN1 | |
| SCHEMBL20056410 | 0.82 | CACNA1I (0.66) | CACNA1IKCNH2CACNA1HCYP2D6CCR2 | |
| SCHEMBL4271203 | 0.82 | CACNA1I (0.74) | CACNA1IKCNH2CACNA1HCYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |