Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | CACNA1I | Q9P0X4 | 9/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4279234 | 0.94 | MAPT (0.51) | GSK3BCACNA1IKCNH2CACNA1HCYP2D6 | |
| SCHEMBL4269219 | 0.91 | KCNH2 (0.57) | GSK3BCACNA1IKCNH2CACNA1HCYP2D6 | |
| SCHEMBL4277726 | 0.91 | GSK3B (0.48) | GSK3BCACNA1IKCNH2CACNA1HCYP2D6 | |
| SCHEMBL8374137 | 0.91 | CACNA1H (0.49) | GSK3BCACNA1IKCNH2CACNA1HCYP2D6 | |
| SCHEMBL4278093 | 0.90 | KCNH2 (0.59) | GSK3BCACNA1IKCNH2CACNA1HCYP2D6 | |
| SCHEMBL14706527 | 0.89 | GSK3B (0.46) | GSK3BCACNA1IKCNH2CACNA1HCYP2D6 | |
| SCHEMBL4273491 | 0.86 | MAPT (0.52) | GSK3BCACNA1IKCNH2CACNA1HCYP2D6 | |
| SCHEMBL4272829 | 0.84 | CACNA1I (0.53) | GSK3BCACNA1IKCNH2CACNA1HCYP2D6 | |
| SCHEMBL4274433 | 0.84 | CACNA1I (0.49) | GSK3BCACNA1IKCNH2CACNA1HCYP2D6 | |
| SCHEMBL14770047 | 0.83 | GSK3B (0.63) | GSK3BCACNA1IKCNH2CACNA1HCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |