Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | CA6 | P23280 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | TPMT | P51580 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | TTR | P02766 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2586288 | 0.88 | ACE2 (0.57) | CA12CA1CA2CA4CA6 | |
| SCHEMBL7674114 | 0.88 | TSHR (0.60) | CA12CA1CA2CA4CA6 | |
| SCHEMBL1989676 | 0.85 | TSHR (0.57) | CA12CA1CA2CA4CA6 | |
| SCHEMBL4695867 | 0.83 | CA12 (0.65) | CA12CA1CA2CA4CA6 | |
| Veratric Acid SCHEMBL11252316 | 0.79 | CA12 (0.74) | CA12CA1CA2CA4CA6 | |
| SCHEMBL1353340 | 0.79 | CA12 (0.62) | CA12CA1CA2CA4CA6 | |
| SCHEMBL18031240 | 0.77 | CA12 (0.65) | CA12CA1CA2CA4CA6 | |
| SCHEMBL4980642 | 0.77 | ADRA1A (0.60) | CA12CA1CA2CA7CA9 | |
| SCHEMBL16306959 | 0.76 | GLA (0.42) | TSHRHTTLMNAMAPTL3MBTL1 | |
| SCHEMBL16294121 | 0.76 | GLA (0.42) | TSHRHTTLMNAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3309146-A1 | SULFONAMIDE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF | University of Tsukuba (JP) | 2018-04-18 | — | — | EP | disclosed |