SCHEMBL2005886

SCHEMBL2005886

COc1cc(C2(c3ccc(O)c(OC)c3)C3CC4CC(C3)CC2C4)ccc1O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.46
CA2 P00918 2/20 0.42
NR3C1 P04150 1/20 0.42
ALOX5 P09917 1/20 0.42
PTPN1 P18031 1/20 0.42
PPARG P37231 1/20 0.42
PPARD Q03181 1/20 0.42
KMT2A Q03164 3/20 0.41
MEN1 O00255 2/20 0.41
SLC22A6 Q4U2R8 1/20 0.41
SLC22A8 Q8TCC7 1/20 0.41
RAB9A P51151 1/20 0.41
ALDH1A1 P00352 3/20 0.40
HSD11B1 P28845 1/20 0.40
GAA P10253 2/20 0.40
SHBG P04278 2/20 0.40
TRPA1 O75762 1/20 0.40
POLB P06746 1/20 0.40
GFER P55789 1/20 0.40
QDPR P09417 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3981612 0.83 GAA (0.45) KMT2AMEN1RAB9AALDH1A1GAA
SCHEMBL3978480 0.81 PTPN1 (0.40) CA2ALOX5PTPN1PPARDKMT2A
SCHEMBL3754199 0.81 MEN1 (0.59) KMT2AMEN1HSD11B1GAAPOLB
SCHEMBL31030078 0.80 ESR1 (0.50) KMT2AMEN1HSD11B1GAAPOLB
SCHEMBL1238135 0.80 ESR1 (0.50) KMT2AMEN1HSD11B1GAAPOLB
SCHEMBL2002660 0.78 KMT2A (0.53) MAOBCA2NR3C1ALOX5PTPN1
SCHEMBL3976002 0.77 MEN1 (0.42) CA2KMT2AMEN1ALDH1A1HSD11B1
SCHEMBL2710599 0.77 GAA (0.42) CA2KMT2AMEN1ALDH1A1HSD11B1
SCHEMBL3976577 0.77 MEN1 (0.42) KMT2AMEN1HSD11B1GAAPOLB
SCHEMBL3974982 0.77 MEN1 (0.42) KMT2AMEN1HSD11B1GAAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7960483-B2 Adamantane derivative, composition comprising the derivative, and optical and electronic member using the composition IDEMITSU KOSAN CO., LTD. (JP) 2011-06-14 US disclosed
EP-1469026-B1 AROMATIC POLYCARBONATE RESIN PROCESS FOR PRODUCING THE SAME OPTICAL PART MOLDING MATERIAL AND OPTICAL PART IDEMITSU KOSAN CO (JP) 2009-05-06 EP disclosed
US-20090062481-A1 ADAMANTANE DERIVATIVE, COMPOSITION COMPRISING THE DERIVATIVE, AND OPTICAL AND ELECTRONIC MEMBER USING THE COMPOSITION IDEMITSU KOSAN CO., LTD. (JP) 2009-03-05 US disclosed
EP-1985617-A1 ADAMANTANE DERIVATIVE, COMPOSITION COMPRISING THE DERIVATIVE, AND OPTICAL AND ELECTRONIC MEMBER USING THE COMPOSITION Idemitsu Kosan Co., Ltd. (JP) 2008-10-29 EP disclosed
US-7329718-B2 Aromatic polycarbonate resin, process for producing the same, optical-part molding material, and optical part IDEMITSU KOSAN CO., LTD. (JP) 2008-02-12 US disclosed
US-20060270823-A1 Suited to a molding material for an optical disc substrate such as a digital audio disc, a digital video disc and an optical memory disc, various lenses such as a lens for an optical pickup, spectacle lenses, contact lenses and a lens sheet, an optical sheet substrate IDEMITSU KOSAN CO., LTD (JP) 2006-11-30 US disclosed
US-7112644-B2 Aromatic polycarbonate resin, process for producing the same, optical-part molding material, and optical part IDEMITSU KOSAN CO., LTD. (JP) 2006-09-26 US disclosed
US-20050143553-A1 Aromatic polycarbonate resin, process for producing the same, optical-part molding material, and optical part IDEMITSU KOSAN CO., LTD (JP) 2005-06-30 US disclosed
EP-1469026-A1 AROMATIC POLYCARBONATE RESIN PROCESS FOR PRODUCING THE SAME OPTICAL PART MOLDINGMATERIAL AND OPTICAL PART IDEMITSU KOSAN CO., LTD. (JP) 2004-10-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090062481-A1 ADAMANTANE DERIVATIVE, COMPOSITION COMPRISING THE DERIVATIVE, AND OPTICAL AND ELECTRONIC MEMBER USING THE COMPOSITION APP, ADAM17, PSD MAOB 2408/4885CA2 3503/4885NR3C1 2443/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.