Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31599421 | 0.83 | HTR2A (0.47) | MTNR1ABRD4CREBBPGAAMAPT | |
| SCHEMBL20169747 | 0.83 | HTR2A (0.47) | MTNR1ABRD4CREBBPGAAMAPT | |
| SCHEMBL14471642 | 0.83 | HTR2A (0.47) | MTNR1ABRD4CREBBPGAAMAPT | |
| SCHEMBL22955423 | 0.80 | CREBBP (0.59) | MTNR1ABRD4CREBBPGAAMAPT | |
| SCHEMBL549073 | 0.80 | CREBBP (0.59) | MTNR1ABRD4CREBBPGAAMAPT | |
| SCHEMBL11491245 | 0.80 | MTNR1A (0.37) | MTNR1ABRD4CREBBPGAAMAPT | |
| SCHEMBL11391465 | 0.79 | MTNR1A (0.54) | MTNR1ABRD4CREBBPGAAMAPT | |
| SCHEMBL14454193 | 0.79 | GAA (0.42) | MTNR1ABRD4CREBBPGAAMAPT | |
| SCHEMBL550098 | 0.77 | CREBBP (0.44) | MTNR1ABRD4CREBBPGAAMAPT | |
| SCHEMBL20330128 | 0.77 | MTNR1A (0.56) | MTNR1ABRD4CREBBPGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3313884-B9 | ANTI-CD123 ANTIBODIES AND CONJUGATES AND DERIVATIVES THEREOF | IMMUNOGEN INC (US) | 2021-05-19 | — | — | EP | disclosed |
| EP-3769787-A1 | CONJUGATES OF CYSTEINE ENGINEERED ANTIBODIES | ImmunoGen, Inc. (US) | 2021-01-27 | — | — | EP | disclosed |
| EP-3313884-B1 | ANTI-CD123 ANTIBODIES AND CONJUGATES AND DERIVATIVES THEREOF | IMMUNOGEN INC (US) | 2020-11-18 | — | — | EP | disclosed |
| EP-3189056-B1 | CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN INC (US) | 2020-06-10 | — | — | EP | disclosed |
| EP-3100745-B1 | NOVEL BENZODIAZEPINE DERIVATIVES | IMMUNOGEN INC (US) | 2018-04-18 | — | — | EP | disclosed |