Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1969886 | 0.90 | HSD11B1 (0.67) | HSD11B1IDH1 | |
| SCHEMBL1969736 | 0.81 | HSD11B1 (1.00) | HSD11B1IDH1 | |
| SCHEMBL1969210 | 0.81 | HSD11B1 (1.00) | HSD11B1IDH1 | |
| SCHEMBL1969737 | 0.81 | HSD11B1 (1.00) | HSD11B1IDH1 | |
| SCHEMBL3246647 | 0.79 | HSD11B1 (1.00) | HSD11B1IDH1 | |
| SCHEMBL12571126 | 0.79 | HSD11B1 (1.00) | HSD11B1IDH1 | |
| SCHEMBL3401273 | 0.79 | HSD11B1 (1.00) | HSD11B1IDH1 | |
| SCHEMBL2011249 | 0.79 | HSD11B1 (1.00) | HSD11B1IDH1 | |
| SCHEMBL1967745 | 0.78 | HSD11B1 (0.77) | HSD11B1IDH1 | |
| SCHEMBL2007463 | 0.78 | HSD11B1 (0.73) | HSD11B1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964618-B2 | 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetic acid, for example; compounds possess human 11- beta-hydroxysteroid dehydrogenase type1 enzyme (11 beta HSD1) inhibitory activity and accordingly have value in treatment of disease states including metabolic syndrome | ASTRAZENECA AB (SE) | 2011-06-21 | — | — | US | disclosed |