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SCHEMBL20060669

SCHEMBL20060669

Cc1ccc(-n2nc(C)cc2NC(=O)Nc2ccc(Oc3ccnc(NC(=O)CNC(=O)CS(C)(=O)=O)c3)c3ccccc23)cc1

nearest known ligand 0.66

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MAPK12 P53778 15/20 0.66
▸ MAPK14 Q16539 15/20 0.66
▸ HCK P08631 12/20 0.66
▸ SRC P12931 9/20 0.66
▸ GSK3A P49840 7/20 0.66
▸ SYK P43405 6/20 0.66
▸ GSK3B P49841 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12541228 0.93 MAPK12 (0.78) MAPK12MAPK14HCKSRCGSK3A
SCHEMBL20060661 0.90 MAPK14 (0.78) MAPK12MAPK14HCKSRCGSK3A
SCHEMBL2533208 0.88 MAPK12 (0.82) MAPK12MAPK14HCKSRCGSK3A
SCHEMBL20060634 0.87 MAPK14 (0.67) MAPK12MAPK14HCKSRCGSK3A
SCHEMBL14701833 0.87 MAPK14 (0.85) MAPK12MAPK14HCKSRCGSK3A
SCHEMBL20036718 0.86 MAPK14 (0.64) MAPK12MAPK14HCKSRCGSK3A
SCHEMBL20060609 0.85 MAPK14 (0.63) MAPK12MAPK14HCKSRCGSK3A
SCHEMBL20060583 0.85 MAPK14 (0.68) MAPK12MAPK14HCKSRCGSK3A
SCHEMBL20060611 0.85 MAPK14 (0.62) MAPK12MAPK14HCKSRCGSK3A
SCHEMBL20060620 0.84 MAPK14 (0.67) MAPK12MAPK14HCKSRCGSK3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582433-B1 UREIDO-PYRAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF RHINOVIRUS INFECTIONS RESPIVERT LTD (GB) 2018-04-18 — — EP disclosed