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SCHEMBL20060697

SCHEMBL20060697

Cc1ccc(-n2nc(C)cc2NC(=O)Nc2ccc(Oc3ccnc(NC(=O)NC4CCN(C)CC4)c3)c3ccccc23)cc1

nearest known ligand 0.65

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MAPK14 Q16539 14/20 0.65
▸ MAPK12 P53778 10/20 0.65
▸ SRC P12931 10/20 0.61
▸ HCK P08631 9/20 0.61
▸ GSK3A P49840 7/20 0.61
▸ SYK P43405 6/20 0.61
▸ GSK3B P49841 1/20 0.61
▸ BRAF P15056 3/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13504135 0.92 MAPK14 (0.77) MAPK14MAPK12SRCHCKGSK3A
SCHEMBL20663723 0.88 MAPK14 (0.60) MAPK14MAPK12SRCHCKGSK3A
SCHEMBL2527570 0.88 MAPK14 (0.81) MAPK14MAPK12SRCHCKGSK3A
SCHEMBL12540421 0.87 MAPK14 (0.77) MAPK14MAPK12SRCHCKGSK3A
SCHEMBL20060625 0.87 MAPK14 (0.62) MAPK14MAPK12SRCHCKGSK3A
SCHEMBL16240690 0.87 MAPK14 (0.79) MAPK14MAPK12SRCHCKGSK3A
SCHEMBL1695605 0.85 MAPK14 (0.72) MAPK14MAPK12SRCHCKGSK3A
SCHEMBL1694481 0.85 MAPK14 (0.76) MAPK14MAPK12SRCHCKGSK3A
SCHEMBL20060580 0.85 MAPK14 (0.62) MAPK14MAPK12SRCHCKGSK3A
SCHEMBL20060583 0.84 MAPK14 (0.68) MAPK14MAPK12SRCHCKGSK3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582433-B1 UREIDO-PYRAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF RHINOVIRUS INFECTIONS RESPIVERT LTD (GB) 2018-04-18 — — EP disclosed