Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL28569781 | 0.93 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CAKLKB1 | |
| SCHEMBL28569777 | 0.92 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CAKLKB1 | |
| SCHEMBL28569778 | 0.92 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CAKLKB1 | |
| SCHEMBL20061424 | 0.78 | PIK3CD (0.46) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL20067909 | 0.73 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL20061425 | 0.72 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL20081276 | 0.72 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL13063170 | 0.70 | PIK3CD (0.80) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL20061338 | 0.68 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL3772446 | 0.68 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180105527-A1 | HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105527-A1 | HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT | WEE2, WEE1, ITK | PIK3CD 14/4885PIK3CG 19/4885PIK3CB 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.