Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 9/20 | 0.39 |
| ▸ | KLK1 | P06870 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20061422 | 0.93 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3CBPIK3CAKLKB1 | |
| SCHEMBL28569777 | 0.91 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CAKLKB1 | |
| SCHEMBL28569778 | 0.91 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CAKLKB1 | |
| SCHEMBL20067909 | 0.72 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL20061424 | 0.71 | PIK3CD (0.46) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL20061425 | 0.71 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL20081276 | 0.71 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL13063170 | 0.69 | PIK3CD (0.80) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL20061338 | 0.67 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL3772446 | 0.67 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107690433-B | Heteroaryl derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating PI3 kinase-associated diseases comprising the same as active ingredient | 韩国化学研究院 | 2021-04-09 | — | — | CN | disclosed |