Sugi Predict

Sugi Predict / Compounds / SCHEMBL20061667

SCHEMBL20061667

SCHEMBL20061667

CC(C)C(C)Cc1cnc2ccccc2n1

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ PDE10A Q9Y233 11/20 0.58
▸ CYP1A2 P05177 1/20 0.52
▸ CYP2C9 P11712 1/20 0.52
▸ HIF1A Q16665 1/20 0.52
▸ MEN1 O00255 2/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ MAPT P10636 1/20 0.50
▸ SMN1; SMN2 Q16637 2/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ RXFP1 Q9HBX9 1/20 0.40
▸ KDM4E B2RXH2 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ FAAH O00519 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24996159 1.00 PDE10A (0.58) PDE10ACYP1A2CYP2C9HIF1AMEN1
SCHEMBL20132769 0.97 PDE10A (0.55) PDE10ACYP1A2CYP2C9HIF1AMEN1
SCHEMBL15508293 0.85 PDE10A (0.62) PDE10ACYP1A2CYP2C9HIF1AMEN1
Hydrochloric Acid SCHEMBL15555434 0.81 PDE10A (0.49) PDE10ACYP1A2CYP2C9HIF1AMEN1
SCHEMBL28818218 0.78 PDE10A (0.62) PDE10ACYP1A2CYP2C9HIF1AMEN1
SCHEMBL29598091 0.76 PDE10A (0.60) PDE10ACYP1A2CYP2C9HIF1AMEN1
SCHEMBL27963773 0.76 PDE10A (0.50) PDE10ACYP1A2CYP2C9HIF1AMEN1
SCHEMBL31694655 0.75 PDE10A (0.69) PDE10ACYP1A2CYP2C9HIF1AMEN1
SCHEMBL5792272 0.75 PDE10A (0.69) PDE10ACYP1A2CYP2C9HIF1AMEN1
SCHEMBL12066225 0.74 PDE10A (1.00) PDE10AMEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230038124-A1 NOVEL SUBSTITUTED CONDENSED RING COMPOUND Sumitomo Pharma Co., Ltd. (JP) 2023-02-09 — — US disclosed
US-10428065-B2 Isoxazolyl substituted imidazopyridines CELLCENTRIC LTD (GB) 2019-10-01 — — US disclosed
US-20180127402-A1 ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES CELLCENTRIC LTD (GB) 2018-05-10 — — US disclosed
US-20180105519-A1 ISOXAZOLYL SUBSTITUTED IMIDAZOPYRIDINES CELLCENTRIC LTD (GB) 2018-04-19 — — US disclosed
US-20180105519-A1 ISOXAZOLYL SUBSTITUTED IMIDAZOPYRIDINES CELLCENTRIC LTD (GB) 2018-04-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180105519-A1 ISOXAZOLYL SUBSTITUTED IMIDAZOPYRIDINES EP300, HDAC3, HDAC1 PDE10A 3820/4885CYP1A2 2584/4885CYP2C9 1566/4885
US-20180127402-A1 ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES EP300, HDAC3, HDAC1 PDE10A 3232/4885CYP1A2 2680/4885CYP2C9 891/4885
US-20230038124-A1 NOVEL SUBSTITUTED CONDENSED RING COMPOUND CYP51A1, HDAC11, MMP9 PDE10A 1228/4885CYP1A2 1078/4885CYP2C9 456/4885
US-10428065-B2 Isoxazolyl substituted imidazopyridines EP300, HDAC3, HDAC1 PDE10A 3820/4885CYP1A2 2584/4885CYP2C9 1566/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.