Sugi Predict

Sugi Predict / Compounds / SCHEMBL2006292

SCHEMBL2006292

SCHEMBL2006292

CCc1coc(-c2ccc(OCCCOc3ccc4[nH]c(C(C)C(=O)O)c(C)c4c3)cc2)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PPARA Q07869 7/20 0.41
▸ PPARG P37231 6/20 0.41
▸ NR1I2 O75469 1/20 0.37
▸ KDM4E B2RXH2 2/20 0.37
▸ MAPT P10636 2/20 0.37
▸ HPGD P15428 2/20 0.37
▸ LMNA P02545 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ PDE3B Q13370 4/20 0.35
▸ PDE3A Q14432 4/20 0.35
▸ P2RY12 Q9H244 4/20 0.35
▸ FFAR1 O14842 1/20 0.35
▸ HRH3 Q9Y5N1 1/20 0.35
▸ GABRA1 P14867 1/20 0.35
▸ GABRG2 P18507 1/20 0.35
▸ GABRB3 P28472 1/20 0.35
▸ GABRA5 P31644 1/20 0.35
▸ GABRA3 P34903 1/20 0.35
▸ GABRA2 P47869 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2002583 0.91 PPARA (0.40) PPARAPPARGKDM4EHSD17B10PPARD
SCHEMBL2001143 0.87 NR1I2 (0.36) PPARAPPARGNR1I2KDM4EMAPT
SCHEMBL2005443 0.86 PPARG (0.39) PPARAPPARGNR1I2KDM4EHSD17B10
SCHEMBL1998658 0.83 PPARG (0.42) PPARAPPARGHTTFFAR1HRH3
SCHEMBL1998655 0.83 PPARA (0.43) PPARAPPARGPDE3BPDE3AP2RY12
SCHEMBL2006818 0.79 S1PR5 (0.40) PPARAPPARGNR1I2
SCHEMBL2001195 0.79 PPARA (0.50) PPARAPPARGNR1I2PPARD
SCHEMBL2006523 0.77 PPARD (0.56) PPARAKDM4EHPGDPPARDALDH1A1
SCHEMBL2000348 0.76 PPARD (0.53) PPARANR1I2PPARD
SCHEMBL12568529 0.76 PPARA (0.41) PPARAPPARGFFAR1HRH3PPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7964622-B2 Indole acetic acid derivatives and their use as pharmaceutical agents BAYER HEALTHCARE LLC (US) 2011-06-21 — — US disclosed
US-20090298854-A1 Indole acetic acid derivatives and their use as pharmaceutical agents MA XIN 2009-12-03 — — US disclosed
US-7592361-B2 (5-{3-[4-(4,5,6,7-tetrahydro-benzooxazol-2-yl)-phenoxy]-propoxy}-indol-1-yl)-acetic acid; diabetes, obesity, hyperlipidemia, and atherosclerotic disease BAYER PHARMACEUTICALS CORPORATION (US) 2009-09-22 — — US disclosed
US-20060264486-A1 Indole acetic acid derivatives and their use as pharmaceutical agents BAYER HEALTHCARE LLC 2006-11-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090298854-A1 Indole acetic acid derivatives and their use as pharmaceutical agents IDO1, IDO2, AADAT PPARA 243/4885PPARG 347/4885NR1I2 3205/4885
US-20060264486-A1 Indole acetic acid derivatives and their use as pharmaceutical agents IDO1, IDO2, AADAT PPARA 243/4885PPARG 347/4885NR1I2 3205/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.